There is no determinable time frame for this and will depend on variables such as stock level and room temperature. We recommend that you are familiar with the Australian guidelines for Vaccine Storage, Strive for 5 and that your cold chain management system accords with the guidance it provides. For more information about the correct storage of vaccines, please contact one of our experienced support staff. Strive for 5 guidelines can be downloaded here at http://www.immunise.health.gov.au/.